







Shear-force spray mode: Delivers 4 to 15 psi to support effective pressure-assisted wound cleansing and debridement, particularly for irregular, deep, or hard-to-reach wounds.
Gentle mist mode: Delivers a soft moisturizing spray at <1 psi, making it well suited for painful, sensitive, or fragile wounds requiring low-trauma application.
Soak
Apply Combatic Lavage for 2-3 mins
Reapeat daily or as directed by your healthcare professional.

ComBatic™ Hydro-Gel combines a bioabsorbable, water-based polymer with Combiotic™, a proprietary non-traditional antimicrobial platform designed to support optimal wound healing, moisture balance, and biofilm disruption.

The optimized polymer network enables sustained, controlled release of active ingredients while maintaining an optimal wound microenvironment over extended periods. Carefully adjusted pH supports natural and accelerated wound healing.

In dry wounds, the hydrogel releases moisture to hydrate the wound bed. In highly exudative wounds, the polymer absorbs excess fluid to maintain an optimal healing environment.

Synergistic plant-based small molecules disrupt bacterial cell membranes without affecting human cells while increasing glutathione (GSH) levels, supporting antioxidant and anti-inflammatory activity.

Inorganic salts impact sulphur homeostasis, reactive oxygen species (ROS) production, energy pathways, and bacterial membrane integrity to support broad-spectrum antimicrobial activity.

Disrupts microbial membranes and biofilm structure, enhances antimicrobial efficacy without driving resistance, exhibits anti-inflammatory and antioxidant effects, and preserves healthy mammalian cells while targeting pathogens.
Effective against 17 WHO priority pathogens, including Gram-positive and Gram-negative bacteria, and fungi (yeasts and molds).
Read Validation DocumentDemonstrated superior antimicrobial performance compared to commonly used antibiotics and silver against clinical isolates.
Read Validation DocumentDemonstrated effective eradication of both single clinical isolates and mixed microbial populations (Gram-positive, Gram-negative bacteria, and fungi). In contrast, most commercially available products showed limited or no activity, especially against mixed populations.
Read Validation DocumentDemonstrated efficacy against both clinical and laboratory isolates in single-species and mixed microbial populations.
Read Validation DocumentDemonstrated in multiple in-house and GMP-level third-party laboratory studies.
Read Validation DocumentIn third-party GLP-level and in-house mouse and pig wound models, MRSA-infected and non-infected wounds demonstrated faster healing compared to standard of care.
Read Validation DocumentNo resistance was observed during testing, whereas resistance to silver and ciprofloxacin emerged on Days 1 and 3, respectively.
Read Validation DocumentNo cytotoxicity was observed in L-929 cells following 24-hour exposure (ISO 10993-5), with results confirmed by GMP-level third-party MEM elution testing in accordance with ISO 10993-12.
Read Validation DocumentValidated in third-party GLP-level biocompatibility and toxicity studies, demonstrating safety for repeated use.
Read Validation DocumentEasy to apply and compatible with standard dressings.
Read Validation DocumentFormulated with a carefully adjusted pH to provide an optimal wound environment and support the natural wound healing process.
Read Validation DocumentIn a GMP-level third-party mouse systemic injection study conducted in accordance with ISO 10993-11, no mortality or evidence of systemic toxicity was observed.
Read Validation DocumentIn a GMP-level third-party guinea pig maximization sensitization study conducted in accordance with ISO 10993-10, no evidence of delayed contact hypersensitivity was observed, and the test article was not considered a sensitizer.
Read Validation DocumentLAL-test (USP <85>) conducted by a GMP-level third-party laboratory successfully passed the endotoxin test requirements.
Read Validation DocumentA GMP-level third-party material-mediated rabbit pyrogen test conducted in accordance with USP <151> demonstrated non-pyrogenicity and met ISO 10993-11 acceptance criteria.
Read Validation DocumentNo irritation was observed in a GMP-level third-party intracutaneous injection study in New Zealand White rabbits conducted in accordance with ISO 10993-23.
Read Validation DocumentGMP-level third-party stability studies passed Antimicrobial Effectiveness Test USP <51>, Total Yeasts and Molds Count (TYMC) USP <61>, Total Aerobic Microbial Count (TAMC) USP <61>, Potential of Hydrogel (pH) USP <791>, Visual Uniformity USP <3>, Viscosity USP <912>, Appearance USP <3>, and pathogen suitability testing for E. coli, Salmonella, P. aeruginosa, and S. aureus.
Read Validation DocumentThe shear-force spray mode is designed to deliver controlled pressure between 4 and 15 psi. This mode can support effective wound cleansing and pressure-assisted debridement.
It may be useful for:
| Use Case | Purpose |
|---|---|
| Contaminated wounds | Helps remove debris and microbial contamination |
| Irregular wound beds | Helps reach uneven wound surfaces |
| Deep or hard-to-access wounds | Helps deliver solution into difficult areas |
| Biofilm-suspected wounds | Supports physical disruption and removal of biofilm-associated material |
| Wound bed preparation | Helps prepare the wound before hydrogel and dressing application |
The gentle mist mode delivers a soft moisturizing spray at less than 1 psi. It is designed for wounds where low-trauma application is important.
It may be useful for:
| Use Case | Purpose |
|---|---|
| Painful wounds | Provides a softer application experience |
| Fragile tissue | Reduces mechanical stress during cleansing |
| Sensitive wounds | Supports gentle hydration and cleansing |
| Superficial wounds | Allows broad and even coverage |
| Long-term care or home care | Makes application easier and more patient-friendly |
No. ComBaticTM Lavage-Spray is designed to be used directly during wound cleansing and wound bed preparation. There is no need to rinse the wound with another solution after application.
After use, the clinician or caregiver can continue with the recommended wound-care protocol, including hydrogel application and dressing placement.
The frequency depends on the wound condition, amount of exudate, presence of biofilm or infection signs, dressing-change frequency, and clinical judgment.
In many cases, it can be used during dressing changes. Depending on the wound-care plan, this may range from twice daily to once daily, or less frequently such as every other day.
ComBaticTM Lavage-Spray can be used as part of wound cleansing, irrigation, and wound bed preparation. For routine cleansing, it may be sprayed directly onto the wound surface to remove debris and contamination.
For wounds with suspected biofilm or higher microbial burden, the solution may be applied to sterile gauze and left in contact with the wound for a short period before continuing with standard wound care. The contact time may depend on the wound condition and clinical protocol.
Yes. ComBaticTM Lavage-Spray is designed to prepare the wound bed before hydrogel application and dressing. It helps cleanse the wound, reduce microbial burden, and create a cleaner wound environment for the next step of care.
A typical workflow may include:
| Step | Action |
|---|---|
| 1 | Cleanse or irrigate the wound with ComBaticTM Lavage-Spray |
| 2 | Use shear-force mode if stronger cleansing or debridement support is needed |
| 3 | Use mist mode if the wound is painful, fragile, or sensitive |
| 4 | Apply ComBaticTM Hydrogel if appropriate |
| 5 | Cover with the selected dressing based on clinical need |
ComBaticTM Antimicrobial Wound Lavage-Spray is an advanced wound cleansing and irrigation product designed to help clean contaminated wounds, reduce microbial burden, and prepare the wound bed before hydrogel application and dressing.
It combines MHCombiotic's proprietary CombioticTM antimicrobial technology with a unique dual-mode spray delivery system. This allows healthcare providers and caregivers to choose between pressure-assisted cleansing and a gentle mist application depending on the wound type, location, pain level, and tissue sensitivity.
Traditional wound cleansers often rely on general antiseptic ingredients such as hypochlorous acid, PHMB, iodine, silver, or saline. While these products may help clean wounds or reduce microorganisms, some antiseptics can also affect healthy cells, especially with repeated use or prolonged exposure.
ComBaticTM Lavage-Spray is designed to go beyond simple cleansing. Its dual-mode spray system also gives users more control, allowing stronger irrigation when needed and a soft mist when the wound is painful, sensitive, or fragile.
The ComBaticTM Lavage-Spray uses a dual-mode spray head that allows the user to switch between two application formats:
| Spray Mode | Pressure Range | Best Used For |
|---|---|---|
| Shear-force spray mode | 4 to 15 psi | Pressure-assisted cleansing, wound irrigation, hard-to-reach areas, irregular wounds, deeper wounds, and debridement support |
| Gentle mist mode | Less than 1 psi | Painful, sensitive, fragile, superficial, or delicate wounds requiring low-trauma application |
This flexibility helps make the product suitable for a broad range of wound care settings, including clinics, hospitals, long-term care, home care, and field-use environments.
Not all wounds need the same level of cleansing pressure. Some wounds require stronger irrigation to remove debris, contamination, slough, and biofilm-associated material. Other wounds are painful, fragile, or sensitive and require a much gentler approach.
The dual-mode system allows users to adjust the application based on the wound condition. This can improve usability, reduce trauma during cleansing, and support more patient-friendly wound care.
Biofilm is one of the major barriers to wound healing. Microorganisms inside biofilms are protected by a dense matrix, making them harder to remove and more tolerant to many antimicrobial treatments.
Biofilms can maintain inflammation, delay wound closure, and contribute to recurring infection. A wound cleanser with antibiofilm activity can help improve wound bed preparation and support a cleaner healing environment.
Yes. ComBaticTM Lavage-Spray is designed to cleanse infected/contaminated wounds, help reduce wound bioburden, physically disrupt biofilm-associated material, and support wound bed preparation.
Wounds with signs of localized infection should be assessed and managed according to healthcare provider guidance. Severe, spreading, or systemic infection requires medical evaluation and may require additional interventions.
Yes. The shear-force spray mode is designed to support pressure-assisted wound cleansing and debridement. It delivers controlled pressure between 4 and 15 psi, which can help remove debris, contamination, slough, and biofilm-associated material from the wound surface.
The formulation also includes a naturally derived surfactant system that helps with debridement, making wound bed preparation more effective.
Pressure-assisted cleansing can help remove wound debris and microbial contamination more effectively than passive rinsing. It is especially useful for wounds with irregular surfaces, hard-to-reach areas, or suspected biofilm.
ComBaticTM Lavage-Spray provides controlled pressure in the shear-force mode, allowing more effective cleansing while maintaining usability and control.
Many wounds are painful, fragile, or sensitive. Applying liquid with too much pressure can cause discomfort or trauma, especially in delicate tissue.
The gentle mist mode delivers a soft spray at less than 1 psi, allowing low-trauma application. This can be helpful for patients who experience pain during cleansing or for wounds where aggressive irrigation is not appropriate.
Yes. ComBaticTM Lavage-Spray is designed for repeated and long-term wound irrigation as part of routine wound care. The formulation was developed to support wound cleansing while maintaining tissue compatibility. It should be used according to product instructions and healthcare provider guidance.
The product is designed to give users control over the application method. For wounds that are painful or sensitive, the gentle mist mode provides a soft, low-pressure spray at less than 1 psi. For wounds requiring stronger cleansing, the shear-force mode can be used. The appropriate mode should be selected based on wound condition, patient comfort, and clinical judgment.
ComBaticTM Lavage-Spray may be suitable for home-care use. The dual-mode spray format can make application easier for caregivers by providing controlled cleansing options.
Patients with severe, deep, rapidly worsening, or highly painful wounds should seek medical assessment before self-treatment.
ComBaticTM Lavage-Spray is based on MHCombiotic's CombioticTM technology platform, which has been developed through extensive formulation screening, antimicrobial testing, antibiofilm studies, mechanistic studies, and safety-focused evaluations. The platform combines plant-derived small molecules and inorganic salts to improve antimicrobial performance while reducing reliance on traditional antibiotics.