(01). More than 78% of chronic wounds contain biofilm
Malone M, Bjarnsholt T, McBain AJ, et al. The prevalence of biofilms in chronic wounds: a systematic review and meta-analysis of published data. Journal of Wound Care. 2017;26(1):20-25.
https://pubmed.ncbi.nlm.nih.gov/28103163/.
(02). Every 30 seconds a lower limb is amputated globally as a consequence of diabetes
Bilal M, et al. Socioeconomic Deprivation as a Predictor of Lower Limb Amputation in Diabetic Foot Disease. PMC10543925. 2023.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10543925/.
(03). Nearly 50% mortality within 5 years of a diabetic foot ulcer diagnosis
Jiang Y, et al. Global mortality of diabetic foot ulcer: A systematic review and meta-analysis of observational studies. Diabetes/Metabolism Research and Reviews. 2022. PubMed ID: 36054820.
https://pubmed.ncbi.nlm.nih.gov/36054820/.
(04). Up to $16,000 average treatment cost per diabetic foot ulcer episode
Stockl K, et al. Costs of Lower-Extremity Ulcers Among Patients With Diabetes. Diabetes Care. 2004;27(9):2129-2134.
https://diabetesjournals.org/care/article/27/9/2129 /22597/.
(05). Effective against 17 WHO priority pathogens:
— MHCombiotic Published Data Addendum, Fig. 3 (heat map — efficacy against 17 WHO priority pathogens including bacteria and fungi)
— Pormohammad A, et al. Nanomaterials in wound healing and infection control. Antibiotics. 2021;10(5):473.
(06). Faster Healing:
— MHCombiotic Published Data Addendum, Fig. 6 & 7 (MRSA mouse wound model — bacterial load reduction and wound closure vs. Prontosan and saline)
(07). Antibiotic-Free — No risk of resistance:
— MHCombiotic Published Data Addendum, Future Resistance Studies section
— Pormohammad A, Greening D, Turner RJ. Synergism inhibition and eradication activity of silver nitrate/potassium tellurite combination against Pseudomonas aeruginosa biofilm. Journal of Antimicrobial Chemotherapy. 2022;77(6):1635-44.
(08). Safe & Skin-Friendly:
— MHCombiotic Published Data Addendum, Tables 2 & 3 (ISO 10993 full biocompatibility suite — cytotoxicity, acute systemic toxicity, sensitization, pyrogenicity, irritation; conducted by Geneva Laboratories under GLP/GMP)